CONDENSED PYRIDAZINE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT, AN AGENT SHOWING INHIBITORY ACTIVITY WITH RESPECT TO CYCLIC GMP-PHOSPHODIESTERASE

摘要

FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to condensed pyridazine of the general formula (I) where n = 1 or 2; R₁- - hydrogen, halogen atom, nitro-, cyano-, amino-group or 4-hydroxypiperidine-1-yl; R₂ and R₃- - halogen atom or lower alkoxy-group, or R₂ and R₃ form together methylenedihydroxy- -group; symbol ___ means double or simple bond; when ___ is a double bond then X - nitrogen atom and Y means =C-Z where Z - halogen atom, group of the formulas (a), (b), (c), (d), (e), (f); p = 0 or 1; m = 0, 1, 2; R₄ means carbamoyl-, carboxy-, carboxylate-group with cation, alkoxycarbonyl- or dialkylamino-group; R₅ or R₆ means H and other - hydroxyl; R₇ means pyridyl, pyrimidyl or lower hydroxyalkyl; R₈- means H, lower alkyl; R₉- means pyridyl, lower hydroxyalkyl, carboxyalkyl, lower alkoxy-, lower hydroxyalkoxy-group, hydroxymethylpyrrolidinyl, imidazolyl, morpholinyl, pyridylmethyl; when ___ means a simple bond then X means NR₁₀ where R₁₀ means H, carboxymethyl, lower alkoxycarbonylmethyl, tetrahydropyranylalkyl or hydroxyalkyl; Y means carbonyl. Synthesized compounds show inhibitory activity with respect to cyclic GMP-phosphodiesterase. EFFECT: improved method of synthesis. 13 cl, 1 tbl, 73 ex