DIMERIC COMPOUNDS OF 4-PHENYLPIPERIDINE, 4-PHENYL-1,2,3,6- -TETRAHYDROPYRIDINE OR 4-PHENYLPIPERAZINE OR DIMERIC COMPOUNDS OF SPIROCYCLIC PIPERIDINES AND PHARMACEUTICAL COMPOSITION

摘要

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention proposes dimers of compounds 4-phenylpiperidine, 4-phenyl-1,2,3,6-tetrahydropyridine or 4-phenylpiperazine or dimers of spirocyclic piperidine of the general formula (I) where n has values from 1 to 5; R¹-R⁴ mean hydrogen atom, halogen atom, trifluoromethyl-group, C_1-6-alkyl; R⁵ and R⁶ each means hydrogen atom or bound they form ethylene bridge; X means O, S, SO₂, CO or (CH₂)_m where m = 0 or 1, or X means NR⁷ where R⁷ means C_1-6-alkyl, cycloalkyl, phenyl, or X means CR⁸R⁹ where R⁸ and R⁹ are taken from hydroxyl and phenyl optionally substituted with halogen atom and (1) Z¹ means hydrogen atom and Z² means (CH₂)_p where p = 0; Y means N, C or CH and dotted line indicates optional bond, i. e. if Y is C then it means a bond; (2) Z¹ and Y are bound by a simple bond forming spirocyclic structure and in this case Y means C and dotted line indicates the absence of a bond; Z¹ means O, S, (CH₂)_q where q = 1, 2 or 3; or Z¹ means CH₂O,CH₂S,CH₂CH₂O,CH₂CH₂S, CH=CH, CH=CHCH₂,CH₂OCH₂,CH₂SCH₂ and Z² means O, S or (CH₂)_p where p = 0 or 1. Synthesized compounds can be used as ligands of sigma-receptors. Invention relates to a pharmaceutical composition binding sigma-receptors also. EFFECT: improved method of synthesis, sigma-receptor binding. 10 cl, 1 tbl, 14 ex