New human neutrophil-lymphocyte peptide and its fragments

摘要

Peptides of formula (I) are new: Ra-C-Xn-C-Rd (I) Ra = amino or its derivative, or an oligo- or poly-peptide made from natural amino acids (aa), derivatives modified in the side chain and/or their stereoisomers; n = 3-7; X = natural aa as above; Rd = carboxy, its derivative or oligo- or poly-peptide as above. Also new are (1) nucleic acid (II) encoding (I), or its fragments, derivatives and analogues; (2) vectors containing (II); (3) host cells containing this vector; (4) DNA that hybridises with (II) and encodes a polypeptide with human neutrophil-lymphocyte peptide (hNLP) activity; (5) antibody (Ab), antagonist or inhibitor directed against (I); (6) antisense oligonucleotide (AON) that inhibits hNLP expression; (7) vector for producing knock-out mice as a chronic model of maturation disorders of the haematopoietic system.