A Synthetic Peptide Approach for Elucidating the Points of Natural Auto-Antibody Reactivity to Proteolytic Fragments of Human IgG

摘要

There are naturally occurring human antibodies to the F(ab')2 portion of IgG [1]. Extracellular proteases and bacterial enzymes can cleave the IgG hinge region and release the Fc domain (with its effector functions. The human immune repertoire contains auto-antibodies that are directed against endogenous Fab and F(ab')2 fragments [2]. The anti-fragment reactivity is at newly exposed epitopes in the cleaved IgG hinge region.