Process for the preparation of orally active cephalosporin antibiotic - cefixime

摘要

Cefixim of formula I is prepared by reacting an ester of formula II for 1.5 - 2 hours with an inorganic base in a mixture of dimethylformamide (DMF) and water, isolating the cefixim of required purity by acidifying the resulting reaction mixture and drying.