Process for the preparation of orally active cephalosporin antibiotic cefixime

摘要

A process for the preparation of an orally active cephalosporin antibiotic-cefixim, of formula I in which an ester of formula II is reacted for 30 - 90 minutes at room temperature in an organic solvent with an aqueous solution of inorganic base in presence of a phase transfer catalyst, thus allowing that resultant mixture settles till separation of the aqueous and organic phases, isolating the cefixim of required purity from the aqueous layer by acidifying said aqueous layer by acidifying said aqueous layer.