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Empty canine parvovirus capsids having CPV recombinant VP2 and vaccines having such capsids
Empty canine parvovirus capsids having CPV recombinant VP2 and vaccines having such capsids
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机译:具有CPV重组VP2的空犬细小病毒衣壳和具有这种衣壳的疫苗
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摘要
The present invention is a method for the production of a subunit vaccine against canine parvovirus (CPV). The method includes the step wherein a recombinant protein VP2 of CPV is obtained by using the replication of a recombinant baculovirus wherein the gene corresponding to VP2 has been previously inserted in cells of a permissive host. The protein VP2 obtained has the capacity of forming empty VP2 capsids with high immunogenicity and can be provided as a vaccine formulation for protecting dogs against CPV infection the recombinant baculovirus AcMNPV. pCPVEx17 expresses the VP2 of CPV in conditions making possible the formulation of pseudo-viral capsids.
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