首页> 外国专利> Cancer metastasis inhibitor containing a streptococcus agalactiae Ia type or Ib type surface polysaccharide as a main ingredient

Cancer metastasis inhibitor containing a streptococcus agalactiae Ia type or Ib type surface polysaccharide as a main ingredient

机译:以无乳链球菌Ia型或Ib型表面多糖为主要成分的癌转移抑制剂

摘要

The present invention relates to the technology for inhibiting the cancer metastasis, and is aimed at the provision of a pharmaceutical composition for effectively inhibiting the metastasis of the cancer. A cancer metastasis inhibitor according to the present invention is characterized by containing a sugar chain separated from a surface of a Streptococcus agalactiae Ia type or Ib type as a main ingredient. Since the surface sugar chains of the Streptococcus agalactiae Ia type or Ib type have structures similar to surface sugar chains of the cancer cells, the former surface sugar chains adhere to E-selectin appearing in an intravascular endothelial cell, competitively inhibit the adhesion between intravascular endothelial cells and the cancer cells, and effectively prevent of the metastasis of the cancer, when the sugar chains exist in blood of a patient.
机译:本发明涉及抑制癌转移的技术,目的在于提供有效抑制癌转移的药物组合物。根据本发明的癌症转移抑制剂的特征在于,其包含从无乳链球菌Ia型或Ib型的表面分离的糖链作为主要成分。由于无乳链球菌Ia型或Ib型的表面糖链具有与癌细胞的表面糖链相似的结构,因此前者的表面糖链粘附于血管内内皮细胞中出现的E-选择素,竞争性地抑制血管内内皮之间的粘附当糖链存在于患者血液中时,细胞和癌细胞有效地防止了癌症的转移。

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