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Method of making transgenic mice lacking endogenous heavy chains
Method of making transgenic mice lacking endogenous heavy chains
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机译:制备缺乏内源性重链的转基因小鼠的方法
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摘要
The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci. The hosts are produced by repetitive transformations of embryonic stem cells by homologous recombination, preferably in conjunction with breeding. Different strategies are employed for recombination of the human loci randomly or at analogous host loci.
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