Selection of Antigen-Specific, Idiotype-Positive B Cells in Transgenic MiceExpressing a Rearranged M167-mu Heavy Chain Gene

摘要

Flow cytometric analysis of antigen specific, idiotype-positive B celldevelopment in transgenic mice expressing a rearranged M167-micron gene shows that large numbers of phosphocholine (PC)-specific, M167-id+ B cells develop in the spleen and bone marrow of these mice. Random rearrangement of endogenous Vk genes, in the absence of a subsequent receptor-driven selection, should give rise