Application of ErgoLine Derivatives, an ErgoLine Derivative, procedures for Preparation and Pharmaceutical composition containing same.

摘要

The therapeutic application in the treatment of neurodegenerative diseases is derived from the first formula ergolin, wherein R1 represents a hydrogen atom or a C1-C5 tar or C2-C5 linear or branched C1-C5 alquenil or branched group, replaced by C3-C7 cyclopentyl, a hydroxy group or a phenyl group as R3, wherein R3 represents an atom a. Consisting of a group of hydrogen compounds or a group of C1-C5 type C2-C5 alquenil linear or optional resin derivatives or a group of polyhydrogen Xi, or R3 substituted by a group of phenyl (R3 is the second in R3 above), or a group of alcox C1-C5;the symbols in positions 2.3 independently indicate a single or double chemical bond and Z represents a group (CH2) n OH, where n is 0 or an integer from 1 to 3, or a group C (R4) 2 OH where R4 is a C1- C5 alkyl or a phenyl group, or a pharmaceutically acceptable salt thereof. A derivative of formula I is also provided as defined above with the exclusion of 6-methyl-8-beta-hydroxy-10-alpha-methoxy-ergoline, 6-methyl-8-beta-hydroxy-10-beta-methoxy-ergoline, 6-methyl- 8beta-hydroxy-methyl-10alpha-methoxy-ergoline, 6-methyl- -8alpha-hydroxymethyl-10alfa-methoxy-ergoline, 6-methyl-8beta-hydroxymethyl-10alpha - (1-methyleth xi) -ergoline,6-metil-8beta-hidroximetil-10alfa-hidroxi-ergolina 6-metil-8beta-hidroximetil-10beta-hidroxi-ergolina 6-metil-8beta-hidroximetil - 10alfa-metoxi-delta-8 9-ergoleno 8beta-hidroximetil-10alfa