Defective recombinant adenoviruses, prokaryotic and bifunctional plasmids, prokaryotic cell, use of a defective recombinant virus, and pharmaceutical composition

摘要

"DEFECTIVE RECOMBINANT VIRUS AND ADENOVIRUS, PROKARYOTIC AND BIFUNCTIONAL PLASMIDES, PROKARYOTIC CELL, USE OF A DEFECTIVE RECOMBINANT VIRUS, AND PHARMACEUTICAL COMPOSITION". The present invention relates to a defective recombinant virus and preferably to an adenovirus characterized by the fact that it comprises at least two nucleic acids that encode enzymes, proteins and / or distinct cofactors implicated in the level of inverse transport of the cholesterol, said nucleic acids being operably linked to a transcriptional promoter and separated from each other by a sequence encoding an internal entry site of the IRES ribosome. It also refers to plasmid constructs useful to prepare these adenoviruses, the cell transformed by these plasmids or adenoviruses and to pharmaceutical compositions containing said adenoviruses.