Amino-oxides and halomethyl organometallic reagent formed in situ.

摘要

Invention Patent: "AMINO-POXIDES OF ENVIROLDED AND ORGANOMETAL REAGENT FORMED IN SITU". Method for the preparation of an amino oxide where a protected amino-oxide is reacted with an orgamethalic halomethyl reagent in a solvent appropriate at a temperature above 80th C where the said organometallic reagent is formed by the reaction between an organometallic reagent and a dihalomethane, the improvement comprising the flow of protected aminoaldehyde into a mixing zone maintained at a temperature below 0.C,Also flowing the said organometallic halomethyl reagent in the said contact mixing zone in the said blending zone with the protected aminoaldehyde and also removing products from the said aminoaldehyde mixing zone and said organometallic halomethyl reagent. The aminoaldehydes obtained are useful through the opening of amine of the Epoxide ring as intermediaries in the preparation of pharmaceutical products, e.g. HIV protease inhibitors.