Genetically modified cells and their use in the prophylaxis or therapy of disorders.

摘要

Invention Patent: B "GENETICALLY MODIFIED CELLS AND THEIR USE IN PROPHYLAXIS OR DISORDER THERAPY" D. The present invention relates to cells for use in gene therapy, obtainable by a) isolation of cells from the blood or fluid containing cells from the body; b) cultivation of the cells obtained in step a) in a cell culture medium comprising gangliosides, phospholipids, glycolipids and / or growth factors; c) alternatively, immortalization of the cells obtained in step a) or b) by transformation with an oncogene, activation of an oncogene or inactivation of a suppressor gene; and d) alternatively, transfection of the cells obtained in step a) and b) or step c) with a nucleic acid construct for gene therapy, comprising an effector gene that can be targeted by the cell in a specific way, specifically in terms of to the cell cycle, specifically as to the virus and / or hypoxia by suitable promoter systems, and the use of these cells for the production of a therapeutic agent for the treatment of a disorder selected from the group comprising tumors, leukemias, disorders autoimmune, arthritis allergies, inflammation, organ rejection, transplant-versus-host reactions, blood clotting disorders, circulation disorders, anemia, infections, hormone disorders and CNS damage.