Olfactory ensheathing cells genetically modified to secrete GDNF to promote spinal cord repair

摘要

Olfactory ensheathing cell (OEC) transplantation has emerged as a very promising therapy for spinal cord repair. In this study, we tested the ability of genetically modified OECs to secrete high levels of glial cell line-derived neu-rotrophic factor (GDNF) to promote spinal cord repair. The GDNF gene was transduced into OECs using