Recombinant DNA molecule, host cell, methods to prolong tissue graft survival, to increase the response to exogenous interferon therapy in the treatment of cancer and to provide an ifnar! Receptor binding protein, and, ifnar1 binding protein .

摘要

"RECOMBINANT DNA MOLECULES, HOSTING CELL, METHODS TO EXTEND TISSUE GRAFT SURVIVAL, TO INCREASE THE RESPONSE TO EXOGEN THERAPY BY INTERFERON IN THE TREATMENT OF CANCER AND TO PROVIDE A PROTECTION OF LIGATION AND A PROTEIN OF LIGATION ". New proteins IR1B1 AND IR1B4 have been isolated, which bind to IFNAR1 of the type I IFN receptor and function in the cellular response to IFNs. The DNA encoding such proteins, in the sense or antisense orientation, can be administered to increase or inhibit the cellular response to IFNs. Antibodies to proteins can be used to isolate new proteins or to immunodetect them.