Recombinant DNA molecule encoding novel IFNAR1 receptor-binding protein, host cell for expression of said recombinant DNA, method of prolongation of tissue graft survival and method of increasing cellular response to exogenic IFN therapy, novel IFNARI binding proteins, processes of their preparation and molecule exhibiting antibody activity

摘要

Novel proteins IR1B1 and IR1B4 have been isolated which bind to the type I IFN receptor IFNAR1 and function in the cellular response to IFNs. DNA encoding such proteins in either the sense or anti-sense orientation can be administered to either enhance or inhibit the cellular response to IFNs. Antibodies to the proteins can be used for isolation of the new protein or for immunodetection thereof.