首页> 外国专利> IN VITRO IMPEDANCE MEASURING METHOD AND APPARATUS FOR EXAMINATION EFFECTS OF BIOLOGICAL MATERIALS, POTENTIAL PHARMACEUTICALS

IN VITRO IMPEDANCE MEASURING METHOD AND APPARATUS FOR EXAMINATION EFFECTS OF BIOLOGICAL MATERIALS, POTENTIAL PHARMACEUTICALS

机译:体外阻抗测定方法及装置,用于检验生物材料,潜在药物

摘要

A test method and instrument suitable for in vitro determination of the affect of chemical compounds on live cells is based on impedance measurements. A test method and instrument suitable for in vitro determination of the affect of chemical compounds on live cells is based on impedance measurements. Live cells are cultured in a dish complete with a thin-layer electrode system used in micro-electronics. A phase sensitive (lock-in) impedance meter measures complex impedance of cells covering the electrodes prior to and following the addition of compounds under test. When a compound affects the material balance of a cell its physical characteristics undergo measurable changes, and this becomes apparent both in the real and imaginary component of the measured result. The phase sensitive measuring technique ensures a high degree of attenuation of background noise and enhances sensitivity.
机译:适用于体外确定化合物对活细胞影响的测试方法和仪器均基于阻抗测量。适用于体外确定化合物对活细胞影响的测试方法和仪器均基于阻抗测量。将活细胞培养在配有用于微电子学的薄层电极系统的培养皿中。相敏(锁定)阻抗计可在添加被测化合物之前和之后测量覆盖电极的电池的复数阻抗。当化合物影响电池的材料平衡时,其物理特性会发生可测量的变化,这在测量结果的实部和虚部中都显而易见。相敏测量技术可确保高度衰减背景噪声并提高灵敏度。

著录项

  • 公开/公告号HU0000996D0

    专利类型

  • 公开/公告日2000-05-28

    原文格式PDF

  • 申请/专利权人

    申请/专利号HU20000000996

  • 申请日2000-03-06

  • 分类号G01N33/50;

  • 国家 HU

  • 入库时间 2022-08-22 01:56:21

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