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IN VITRO IMPEDANCE MEASURING METHOD AND APPARATUS FOR EXAMINATION EFFECTS OF BIOLOGICAL MATERIALS, POTENTIAL PHARMACEUTICALS
IN VITRO IMPEDANCE MEASURING METHOD AND APPARATUS FOR EXAMINATION EFFECTS OF BIOLOGICAL MATERIALS, POTENTIAL PHARMACEUTICALS
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机译:体外阻抗测定方法及装置,用于检验生物材料,潜在药物
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摘要
A test method and instrument suitable for in vitro determination of the affect of chemical compounds on live cells is based on impedance measurements. A test method and instrument suitable for in vitro determination of the affect of chemical compounds on live cells is based on impedance measurements. Live cells are cultured in a dish complete with a thin-layer electrode system used in micro-electronics. A phase sensitive (lock-in) impedance meter measures complex impedance of cells covering the electrodes prior to and following the addition of compounds under test. When a compound affects the material balance of a cell its physical characteristics undergo measurable changes, and this becomes apparent both in the real and imaginary component of the measured result. The phase sensitive measuring technique ensures a high degree of attenuation of background noise and enhances sensitivity.
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