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Novel pyrido3,2-e pyrazinones with anti-asthmatic action and processes fortheir manufacture
Novel pyrido3,2-e pyrazinones with anti-asthmatic action and processes fortheir manufacture
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机译：具有抗哮喘作用的新型吡啶并[3,2-e]吡嗪酮及其制备方法
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摘要
PyridoÄ3,2-eÜpyrazinone derivs. of formula (I) and their salts are new: A = CH2, NR3 or O; X, Y, Z = N or CR4, provided that 1 of X, Y and Z is N; R1 = H (but only if A = NR3); 1-10C alkyl, 1-10C alkenyl, 1-10C alkynyl, or 5-7C cycloalkyl (all opt. mono- or poly-substd. by OH, 1-6C alkoxy, 1-6C alkenyloxy or 1-6C alkynyloxy; aryl, aryloxy, heteroaryl or heteroaryloxy (all opt. substd.); opt. substd. amino, halo, NO2, CN, C=OR5 or S(O)nR6); n = 0-2; R2 = H; 1-10C alkyl, 1-10C alkenyl, 1-10C alkynyl or 5-7C cycloalkyl (all opt. substd. as for R1); R3 = H or 1-6C alkyl; R4 = H, 1-6C alkyl (opt. substd.) or halo; R5 = H, 1-6C alkyl (opt. substd.), Ph, OH or 1-6C alkoxy; aryloxy or amino (both opt. substd.); R6 = H, 1-6C alkyl, aryl (opt. substd.), OH or 1-6C alkoxy; aryloxy or amino (both opt. substd.).
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机译：PyridoÄ3,2-epyrazinone衍生。式（I）的化合物及其盐是新的：A ＝ CH 2，NR 3或O; X，Y，Z ＝ N或CR 4，条件是X，Y和Z中的1个为N。 R 1 ＝ H（但仅当A ＝ NR 3时）; 1-10C烷基，1-10C烯基，1-10C炔基或5-7C环烷基（均由OH，1-6C烷氧基，1-6C烯基氧基或1-6C炔基氧基单或多取代）;芳基;，芳氧基，杂芳基或杂芳氧基（所有均优选）;优选氨基，卤素，NO 2，CN，C ＝ OR 5或S（O）n R 6）; n = 0-2; R 2 ＝ H; 1-10C烷基，1-10C链烯基，1-10C炔基或5-7C环烷基（对于R 1均为最佳选择）; R 3 ＝ H或1-6C烷基; R 4 ＝ H，1-6C烷基（优选）或卤素; R 5 ＝ H，1-6C烷基（任选的），Ph，OH或1-6C烷氧基;芳氧基或氨基（均可选）; R 6 ＝ H，1-6C烷基，芳基（优选），OH或1-6C烷氧基;芳氧基或氨基（均可选）。
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