Rapid purification of synthetic intermediates and products by polymer supported quench reagents

摘要

A polymer-supported quenching reagents of Formula (I) for the preparation and use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis. P-L-Q (I) P is a polymer of low chemical reactivity including insoluble polymers such as, for example, poly(styrene-divinylbenzene), methacrylic acid/dimethylacrylamide copolymer, poly(styrene-divinylbenzene/poly(ethylenegylcol) copolymer and soluble polymers such as, for example, polystyrene or poly(ethyleneglycol), and the like; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents such as primary amine; secondary amine, tertiary amine, isocyanate, isothiocyanate, carboxylic acid, acid chloride, ketone, aldehyde, and the like; and L is one ore more chemically robust linkers that join P and Q, for example CH2-CH2, CH=CH, CH-N, CH2-N, CH-O, CH2-O, CH-S, CH2-S, C(=O)N, NC(=O),NC(=O)N, N(C=O)O, OC(=O)N, combinations thereof, and the like.