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Benzenesulfonamide derivative

机译:苯磺酰胺衍生物

摘要

Refers to a compound of formula (i), where X is o or NH, and y and Z are each ch and NH; or X is a variable y and Z is n, and the other is CH; R1 and R2 independently represent h,Alkyl C1 - C7, C1 - C7 substituted by Hydroxy alkyl, halogen, alkoxy C1 - C7, carboxy, C1 - C7 - alkoxy alkyl carbonyl, carbamoilo, C1 - C7 Carbon carbomoilo, dialkyl C1 - C7 carbamoilo,Cycloalkyl C3 - C8, or cycloalkyl C3 - C7 C8 substituted by alkoxy carbonyl C1 - C2 or C7 represents alcanoilo; while at least one of the variables R1 or R2 is different HydrogenThe group is nr1r2 alquileno C2 - C6 amino substituted linear or not; The Ring, besides being replaced by so2nr1r2 - and - NH -, is replaced or not, one or more times by alkyl alkoxy C1 C1 - C7, C7,Alkoxy C1 - C7 - C1 - C7 alkoxy, halogen, Hydroxy, and Cf3; The Ring B is replaced or not, one or more times, through one of his carbon C1 - C7 by Halogen, alkyl, alkoxy C1 - C7, carboxy,Alkoxy carbonyl carbon C1 - C7, carbamoilo.It also relates to the use of the compound of formula (i) for the treatment of Obesity and Related Disorders to be antagonists of Neuropeptide y5 receptor Subtype
机译:指式(i)的化合物,其中X为o或NH,且y和Z分别为ch和NH; X为变量y,Z为n,另一个为CH。 R 1和R 2独立地代表被羟基烷基,卤素,烷氧基C 1 -C 7,羧基,C 1 -C 7-烷氧基烷基羰基,氨基脲,C 1 -C 7碳羰基,二烷基C 1 -C 7氨基取代的h,烷基C 1 -C 7,C 1 -C 7。烷氧基羰基C 1 -C 2或C 7取代的环烷基C 3 -C 8或环烷基C 3 -C 7 C 8表示alcanoilo;当变量R1或R2中至少一个不同时,氢是nr1r2alquileno C2-C6氨基取代的直链或不直链的基团;该环除了被so2nr1r2-和-NH-取代外,是否被烷基烷氧基C1-C7-C7,C7,烷氧基C1-C7-C1-C7烷氧基,卤素,羟基和Cf3取代或不取代一次或多次;环B通过卤素,烷基,烷氧基C1-C7,羧基,烷氧羰基碳C1-C7,氨基甲酰胺中的一个碳原子C1-C7取代或不被取代一次或多次。用于治疗肥胖症和相关疾病的式(i)化合物,可作为神经肽y5受体亚型的拮抗剂

著录项

  • 公开/公告号PE01272000A1

    专利类型

  • 公开/公告日2000-03-14

    原文格式PDF

  • 申请/专利权人 NOVARTIS AG;

    申请/专利号PE19980001240

  • 发明设计人 BUEHLMAYER PETER;

    申请日1998-12-17

  • 分类号C07D277/42;A61K31/425;C07D417/12;

  • 国家 PE

  • 入库时间 2022-08-22 01:55:24

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