Hexahidro 1 - - 2- methane - 3 - 6 - 10 - benzazocin trees with N - (substituted phenyl) - 5 - tetrahidrofuranil) methyl N - (6 - methyl phenyl tetrahidropiranil); procedure for preparing them and their use as pharmaceutical compositions.

摘要

1,2,3,4,5,6-HEXAHIDRO-2,6-METANO-3-BENZAZOCIN-10-OLES SUBSTITUTED WITH N- (5-FENIL-TETRAHIDROFURANIL) METHYL AND N- (6-FENYL-TETRAHYDROPYRAMIL) METHYL OF GENERAL FORMULA 1, where: R1 and R2 are H, methyl or fluorine, n 1 or 2, R3 are H, fluor4, Chlorine, bromine, methyl, ethyl, hydroxy, methoxy; R4 and R5 can signify H or methyl; R6 are H, methyl or ethyl). PROCEDURES FOR PREPARING THEM, AND FOR USE AS PHARMACEUTICAL COMPOSITIONS. These compounds will be in the form of optical isomers, enantomers, racemates, free bases. Its therapeutic use is indicated in the therapeutic treatment of arrhythmias, spasms, cardiac and cerebral ischemia,Pain and neurodegenerative disorders of various etiologies The third peptide therapy for epilepsy, hypoglycemia, anoxia, anaerobe, Alzheimer's disease, heart disease, thoracic blood vessels, local anesthetics, etc: bromodiphenyl ether (2R, 5S) - and (2S, 5S) - (5-phenyl) - tetrahydrofuran-2-il) methyl