- hexahidro 1,2,3,4,5, 6 - 2.- methane - 3 - 6 - 10 - benzazocin trees with N - (substituted phenyl) - 5 - tetrahidrofuranil) methyl N - (6 - methyl phenyl tetrahidropiranil); procedures for preparing them and their use as pharmaceutical compositions

摘要

1 - hexahidro - 2.6 - methane - 3 - benzazocin - 10 - trees of General formula 1.File = " EMI 00012191 _ 1" id = "1" = in the MFI JPEG: R1 can be Hydrogen, Methyl or Fluorine; R2 can be Hydrogen, Methyl or FluorineAn integer n can be 1 or 2 can mean; R3 is Hydrogen, Fluorine, Chlorine, Bromine, Methyl, Ethyl, Hydroxy,Methoxy; R4 can be Hydrogen or Methyl; R5 can be Hydrogen or Methyl; R6 can be Hydrogen, Methyl or Ethyl, the compounds in question,Optionally in the form of individual Optical isomers, or mixtures of enantiomers racematos individual, and in the form of Free bases or of the corresponding salts addition,Pharmacologically acceptable acid. Procedure for preparing compounds of General formula 1.File = " EMI 00012191 _ 2" id = "2" mfi = JPEG wherein a Derivative of General formula of nor - benzomorfano EMI 2 file = "00012191 _ 3" id = "3" = JPEG MFIs in the R3, R4,And R6 are defined as in claim 1, it reacts with tetrahydrofuran Derivative of General formula or hexahidropirano 3, EMI file = "00012191 _ 4" id = "4" = JPEG MFIs in which R1R2 and N are defined as in claim 1, and x represents a labile Group can be substituted with a secondary amino Group, and the final product is optionally Purified and isolated.