METHODS AND DIASTEREOMERAL SALTS USEFUL IN THE RACEMATE SEPARATION OF RACEMIC 4- (4- (4- (HYDROXYDIPHENYLMETHYL) -1-PIPERIDINYL) -1- HYDROXYBUTYL) -ALPHA, ALPHA-DIMETHYIGSE-O-SEAL-SEAL-SEAL-E-SEAL-SEAL-SEAL-SEALED-SEALED

摘要

A process and diastereomeric salts useful for the optical resolution of racemic alpha-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol, 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-alpha,alpha-dimethylbenzeneacetic acid and lower alkyl 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-alpha,alpha-dimethylbenzeneacetates. The process comprises placing into solution a chiral resolving agent, either (+)/(-)-di-paratoluoyltartaric acid or (-)/(+)-mandelic acid, in an amount equimolar to a compound corresponding to the desired enantiomer of the above compound, precipitating the resulting diastereomeric salt between the chiral resolving agent and the target enantiomer and separating the enantiomer.