AQUEOUS COMPOSITIONS FOR LONG-TERM STABLE STORAGE OF ADENOVIRUS PARTICLES INCLUDING USES AND METHODS FOR PREPARING SAME

摘要

The present invention addresses the need to improve the long-term storagestability (i.e. infectivity) of vector formulations. In particular, it hasbeen demonstrated that for adenovirus, the use of bulking agents,cryoprotectants and lyoprotectants imparts desired properties that allow bothlyophilized and liquid adenovirus formulations to be stored at 4~C for up to 6months and retain an infectivity between 60-100% of the starting infectivity.