A stabilized aqueous Pharmaceutical composition for long-term Storage comprising etanercept and a Stabilizer to Prevent, inhibit or reduce the presence of particles in the subvisibles composition, where the Stabilizer comprises a Surfactant, and the composition is lib Re of arginine as a Stabilizer.

摘要

The invention provides stabilized aqueous pharmaceutical etanercept compositions suitable for long-term storage of etanercept, with substantial reduction in sub-visible particles, and methods of manufacture of these compositions, methods of administration, and articles of manufacture.