METHODS AND COMPOSITIONS FOR TOLERIZING HOSTS FOR LONG TERM SURVIVAL OF TISSUE TRANSPLANTS

摘要

The invention provides encapsulated cells and methods for the tolerization of a graft recipient host. Encapsulated cells tolerize the host. Concurrent administration of an immunosuppressive agent allows successful transplantation of a desired graft. After tolerization, a graft can be transplanted in the desired location without the sustained use of an immunosuppression or immunotherapy. Thus, the invention provides a method for transplanting genetically modified xenogeneic myoblasts in a peripheral immunoreactive site while ensuring their long-term survival. Through a combination of encapsulation techniques and the use of selected immunosuppressors, a variety of different xenogeneic cell types can now be transplanted.