METHOD OF SYNTHESIS OF 2-SUBSTITUTED BENZOBTHIOPHENE (VARIANTS), METHOD OF SYNTHESIS OF DERIVATIVES OF 2-PHENYL-3-AROYLBENZOBTHIOPHENE (VARIANTS) AND DERIVATIVES OF BENZOBTHIOPHENE

摘要

FIELD: organic chemistry, pharmacy, chemical technology. SUBSTANCE: invention describes the method of synthesis of the novel 2-substituted benzo[b] thiophene of the general formula (I) where values R¹ and R² are given in p. 1 of the invention claim. Method involves the synthesis of boronic acid derivative followed by its coupling with the compound of the formula X-C₆H₄-R² where X means bromine or iodine atoms and R² means H, OH or OR⁴ where R⁴ means hydroxy-protective group. Synthesized compound can be used as an intermediate substance for synthesis of pharmaceutically active compounds being others are useful for treatment of women with osteoporosis in the phase of postmenopause. EFFECT: simplified and decreased cost of process. 32 cl, 1 dwg, 3 ex