NITRO CONNECTIONS AND THEIR PREPARATIONS WITH ANTI-FLAMMING, PAINT RELEASING AND ANTITHROMBOTIC EFFECTS

摘要

PCT No. PCT/EP95/01233 Sec. 371 Date Mar. 6, 1997 Sec. 102(e) Date Mar. 6, 1997 PCT Filed Apr. 4, 1995 PCT Pub. No. WO95/30641 PCT Pub. Date Nov. 16, 1995New compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities, of the general formula: A-X1-NO2 or their salts, wherein: A is R(COXu)t, wherein t is zero or 1 and u is zero or 1; and X is O, NH or NR1C wherein R1C is C1-C10 alkyl; and R is(Ia) wherein R1 is acetoxoy, preferably n ortho-position with respect to -CO- and R2 is hydrogen; or derivatives of acetylsalylsalicyclic acid; and X1 is -YO- wherein Y is C1-C20 alkylene, C5-C7 cycloalkylene, oxy-alkyl derivatives and oxy-methyl benzyl derivatives.