Microfabricated thick-film electrochemical sensor for nucleic acid determination

摘要

A thick-film sensing apparatus for nucleic acid determination and testing using potentiometric stripping analysis, including two methods for nucleic acid detection at the microfabricated strips, both methods being designed for use with the thick-film sensing apparatus. The present invention is applicable for broad use in nucleic acid analysis, particularly for measurement of nucleic acids (e.g., DNA and RNA), and their sequences and interactions, and for detection of DNA damage, at thick-film electrodes, based on stripping potentiometry.