As a marker the green fluorescent protein (GFP) the cancer transfer model which is utilized

摘要

(57) Abstract Manner in order to trace the advance of transfer of the primary tumor is disclosed. This manner becomes removing from the Vertebrata suffering inspection body which as contained the tumor cell which reveals GFP, makes fresh organ system alter, and including the fact that existence of fluorescence is observed with the system which is extracted. It is possible also to monitor fluorescence by observing system with in situ. The Vertebrata suffering inspection body which contains the GFP production tumor is the useful model in order to research the feature of transfer. Furthermore, already treating the suffering inspection body which has the tumor, it is possible in order to possess GFP, to make the tumor alter which is generated inside. Clinical application becomes possible with this. Lastly, it can observe the nerve tube formation in the tumor by injecting the pigment of counter staining to the suffering inspection body which possesses the GFP indicator tumor, directly.