INHIBITOR OF VASCULAR ENDOTHELIAL CELL GROWTH FACTOR AND INHIBITOR OF NEOVASCULARIZATION

摘要

PROBLEM TO BE SOLVED: To obtain the subject inhibitor capable of exhibiting antagonistic activities or the like against the bond of a vascular endothelial cell growth factor(VEGF) to heparan sulfate or heparin present in the vascular endothelial cell by including a sulfated glucosaminopglycan containing a large amount of N-sulfate group and 6-sulfate group.;SOLUTION: This inhibitor contains a sulfated glycosaminoglycan having repeating structure of a disaccharide unit composed of glucosamine and hexuronic acid, as a base skeleton, and its salt. The sulfated glycosaminoglycan and the salt have a composition containing ≥40 mol% ΔDiHS-di(6,N)S of the formula (R1 and R2 are each SO3-; R3 is H) measured by a disaccharide composition analysis combining the degradation by a glycosaminoglycan-splitting enzyme with a high-pressure liquid chromatography, and the salt thereof. The daily dose of the sulfated glycosaminoglycan is exemplified by 100 μg/kg to 100 mg/kg as a clinical dose.;COPYRIGHT: (C)2000,JPO