Reverse hidroxamato inhibitors of Matrix Metalloproteinases, their use in the manufacture of a Medicament, and Pharmaceutical composition comprising the

摘要

Inhibitors of Matrix Metalloproteinases hidroxamato inverse comprising formula (i) or a pharmaceutically aceptabledel Salt or prodrug thereof,Where: is Hydrogen; n is Zero; R1 and R3 are independently selected from the group consisting of: (1) and (2) alkyl Hydrogen C1 - 6; R2 and r4son independently selected from the Group CConsists of: (1) hydrogen, alkyl C1 - 6 (2), (3) alquenilo C1 - 6, alquinilo C1 - 6 (4), (5) alcoxicarbonilalquilo alkoxyalkyl esters, (6),Where alquileno and alkyl groups are independently C1 - 6; (7) haloalquilo C1 - 6; (8) hidroxialquilo, where the Group alquilenoes C1 (9) - 6 - (alquileno) - S (o) P - alkylWhere the alquileno are C1 and the alkyl phenyl - 6 (10), (11) fenilalcoxialquilo, where groups are independently alquileno yalquilo C1 - 6 (12) fenilalquilo,Where the group is alquileno C1 - 6 (13) fenoxialquilo, where the group is alquileno C1 (14) - 6 - (alquileno) - N - phenyl SO2 (R5), where the alquileno is C1 - 6And where R5 is selected from the group consisting of: (a) and (b) hydrogen alkyl (C1 - 6; 15) (oxialquilo heterocycle), where alquileno is C1 - 6 (16) - (alquileno) - S (o) P - heterocycle,Where the group is alquileno C1 - 6; (17) - (alquileno) - heterocycle, where the grupoalquileno is C1 - 6 - ((18), and alquileno) - nr6r7, where the group is alquileno C1 - 6 in (15) to (17),The heterocycle is seleccionadodel group consisting of: (a) piridilo pirazinilo, (b), (c) piridazinilo furilo, (d), (e) (f) tienilo, isoxazolilo oxazolilo, (g), (H) and (i) isothiazolyl, thiazolylWhere yen (10) - (17), phenyl, phenyl portions of fenilalcoxialquilo, fenilalquilo, (alquileno) - N - (R5) and - SO2 -, phenyl fenoxialquilo (alquileno) - S (o) P -, phenyl and Heterocyclic,The Parties of Heterocycles (oxialquileno heterocycle), - (alquileno heterocycle) - and (- alquileno) - S (o) P - sonopcionalmente heterocycle substituted with one,Two or three substituents independently selected from the group consisting of: (a) alkyl C1 - 6, 6 - alkoxy C1 (b), (c) alkoxyalkyl esters,Where the alkyl group and the Group alquileno are independently C1 - 6 (d), (e) Halo, haloalquilo C1 6 hydroxy -, (f), (g) hidroxialquilo C1 - 6