Reveal the glycoprotein (deritropoyetina, these Conjugates comprise a glucoiproteina Erythropoietin that have at least one free amino Group.That presents a Biological activity in vivo to get Bone Marrow Cells increase the production of red blood cells and reticulosis and which is selected from the group of the ERIHuman tropoyetina and analogs thereof,In the primary structure of Human Erythropoietin modified through the addition of between 1 and 6 glycosylation sites or through the provision of at least one ifUncle glycoprotein glycosylation, that is covalently bound to one of three groups Lower alkoxy - poly (ethylene glycol) each group Poly (ethylene glycol).Ra is covalently bound to glycoprotein with a Connector with the Formula - C (o) - X - S - and - C (o), with the Connector forming an amide bond with one of the amino groups.Where X and y are as defined in the description and RevelationsThe Average Molecular Weight of each portion of Poly (ethylene glycol) lies between about 20 kilodaltons and around 40 kilodaltons.And the molecular weight of the conjugate is between about 51 kilodaltons and around 175 KD.
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