USE OF AN AROMATASE INHIBITOR IN THE TREATMENT OF DECREASED ANDROGEN TO ESTROGEN RATIO AND DETRUSOR URETHRAL SPHINCTER DYSSYNERGIA IN MEN AND METHOD TO STUDY THE DYSSYNERGIA IN MALE RODENTS

摘要

The present invention relates to the use of an aromatase inhibitor in the manufacture of a medicament for the treatment of a) detrusor urethral sphincter disorder, which is a medicament for treating a urethral disorder as a result of a declining androgen-estrogen ratio or ii) a decreasing androgen-estrogen ratio. The invention also encompasses an in vivo assay for influencing urinary excretion function in a male subject, wherein the rodent is: - anesthetized; they are used to trigger urine output and record bladder pressure and urine flow over time. SHE