2 - substituents of aminopyridines containing Condensed Ring type.

摘要

The present Invention relates to Derivatives of 2 - aminopiridina of formula I: or pharmaceutically acceptable salts of the same, in which a and B are each independently or together, hA and B form a condensate of the phenyl ring ring ring, being saturated or unsaturated and containing 5 to 7 Atoms in the ring,Where these Atoms in the Ring May optionally include 1 to 2 heteroatoms selected irrespective of the group consisting of N, o or s,Whenever members of two adjacent rings are not heteroatoms; X is Oxygen or a simple Link; and alkyl (C1 - C6); r1 is Hydrogen,Alkyl (C1 - C6) or a Group (C1 - C6 alkyl) - replaced with the nr2r3 in R2 and R3 are selected independently of the group consisting of H, alkyl, aryl, or aralquilo tetrahidronaftaleno,Being said aryl group or the rest of the Group aralquilo aryl phenyl or naphthyl,Alkyl or alkyl containing the rest of the Group aralquilo one to six carbon Atoms and a linear or branched chain, and the aryl Group,The tetrahidroftaleno aryl group or the rest of the aralquilo optionally substituted with one to three Traces of halogen, Nitro, cyano, amino, alkoxy (C1 - C4) and alquilamino (c1-c4),Or R2 and R3 are, together with nitrogen to which they are attached, a Heterocyclic ring, or a cyclic or bicyclic Ring that is saturated or unsaturated.The compounds of the invention are capable of inhibiting the activity of nitric oxide synthases (nos), and are therefore useful in the treatment of diseases,States and central nervous system disorders, among others.