Indole derivatives of 4-yl-1-butyric acid, their preparation and their use as inhibitors alpha1-adrenergic and testosterone 5alpha-reductases receptors.

摘要

The present invention concerns a indole derivative represented by formula (1) or a salt thereof, and a pharmaceutical product containing the derivative or salt: [where R {SUP, 1} represents lower alkyl; R {SUP, 2} represents hydrogen or phenyl which may be substituted by at least a lower alkyl, lower alkoxy or a halogen atom; R {SUP, 3} represents hydrogen, lower alkyl, lower alkoxy, or phenyl WHICH CAN BE REPLACED by halogen or lower alkyl; R {SUP, 4} represents hydrogen, lower alkyl, or lower alkoxy; R {SUP, 5} is hydrogen or loweralkyl; N represents an integer of 1 to 5] .This compound has the effect of blocking RECEPTORS {} {SUB AL, 1} ADRENERGIC E INHIBIT REDUCTASES 5 TESTOSTERONE {AL}, and is useful as a remedy and / or a PREVENTIVE FOR DISEASES Caused by overproduction of dihydrotestosterone, AS Prostatic Hypertrophy, AND DISEASES ACCOMPANYING THE SAME AS DISORDERS OF uRINE, alopecia TYPE MALE, ACNE, and the like.