SYNTHESIS OF OPTICALLY ACTIVE PHENYLALANINE ANALOGS THROUGH MICROBIAL TRANSFORMATIONS

摘要

A biocatalytic process to produce optically activephenylalanine analogs from arylacrylic acids isdisclosed in which Rhodotorula graminis yeastcontaining phenylalanine ammonia-lyase introduces amolecule of ammonia stereoselectively onto the doublebond of a 3-substituted acrylic acid. The substituentat the 3-position of the 3-substituted acrylic acidincludes, for example, aromatic rings such assubstituted phenyl groups, five member aromaticheterocyclics, and six member aromatic heterocyclics.