METHODS AND COMPOSITIONS FOR IDENTIFYING MORPHOGENIC PROTEIN ANALOGS USING MORPHOGENIC PROTEIN RESPONSIVE INHIBITORY ELEMENTS

摘要

The present invention relates generally to methods and compositions foridentifying morphogenic protein analogs. In one embodiment, this inventionrelates to an osteogenic protein reponsive transcription inhibitory element.This invention also relates to the identified morphogenic protein analogswhich can mimic the biological effects of morphogenic proteins, particularlythose relating to the BMP family such as osteogenic protein (OP-1), on theregulation of gene expression and tissue inductive capabilities.