Modulation of he4 in inflammatory and renal diseases

摘要

The invention relates generally to the changes in gene expression in inflammatory diseases and renal diseases such as IgAN and NCGN. The invention relates specifically to a novel HE4 sequence which was identified in IgAN kidney tissue. Methods are described for diagnosing inflammatory and renal diseases, such as immunoglobulin A nephropathy by measuring the levels of HE4 in nucleic acid or cell samples from patients. Also described are methods of screening modulators of HE4.