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INHIBITION OF βARRESTIN MEDIATED EFFECTS PROLONGS AND POTENTIATES OPIOID RECEPTOR-MEDIATED ANALGESIA
INHIBITION OF βARRESTIN MEDIATED EFFECTS PROLONGS AND POTENTIATES OPIOID RECEPTOR-MEDIATED ANALGESIA
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机译:βarrestin介导的作用蛋白和阿片受体介导的镇痛药的抑制作用
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摘要
The present invention provides an arrestin knockout mouse useful for screening compounds for efficacy in controlling pain, methods of controlling pain in subjects by inhibiting binding of arrestin to ν opioid receptors, and methods of screening a compound for activity in potentiating ν opioid receptor agonist activity (e,g., morphine activity) by determining whether or not said compound inhibits arrestin binding to a ν opioid receptor.
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