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Chimeric polypeptides enhancing dimer formation through electrostatic interactions and disulfide bond, method for production and uses thereof
Chimeric polypeptides enhancing dimer formation through electrostatic interactions and disulfide bond, method for production and uses thereof
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机译:通过静电相互作用和二硫键增强二聚体形成的嵌合多肽,其生产方法和用途
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摘要
A chimeric polypeptide consisting of a first and a second polypeptide chain, being chemically linked via 1 to 3 cysteine-based disulfide bridges , characterized in that said first polypeptide chain consists of 1 to 3 cysteines and 4 to 12 basic amino acids preferably selected from the group consisting of arginine, lysine and ornithine and said second polypeptide chain consists of 1 to 3 cysteines and 4 to 12 acidic amino acids selected from the group consisting of glutamate and aspartate, and each of said polypeptide chains is linked at its C- or N-terminus to a biologically active compound, is useful as a multimeric pharmaceutical agent.
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