2-124--1--134- 2-124-TRIAZOLE-1-YL-134-THIADIAZOLE DERIVATIVES HAVING AN EFFECT ON THE C.N.S. AND THE HEART

摘要

The present invention relates to novel 2-a to affect the heart and central nervous system general formula (I) (-1- 1,2,4- triazol-yl) -1,3,4-thiadiazole derivatives, and more particularly relates to a process for preparing a pharmaceutical composition, and a novel compound containing such a derivative:; Formula (I); Wherein; R ¹ is from the hydrogen atom, a C _1-4 alkyl group or a halo atom, a hydroxy group, a nitro group, C _1-4 alkoxy groups, (C _1-4 alkyl) amino groups and di (C _1-4 alkyl) group consisting of amino group substituted by one to three substituents selected or unsubstituted represents an unsubstituted phenyl group; Z represents a hydrogen atom or a C _1-4 alkoxy group, R ⁰ has the formula Alk-NR ⁴ R ⁵ means a group and, Alk is C _1-6 means a straight or branched alkylene, and R ⁴ and R ⁵ are independently a hydrogen atom; C _2-6 alkenyl; Or it contains a hydroxy group, (C _1-4 alkyl) amino group, di (C _1-4 alkyl) amino group, 1 to 3 C _1-4 alkoxy groups and a phenyl group one or more nitrogen atoms or a nitrogen and an oxygen atom which may be substituted by and the nitrogen atom is bonded by a C _1-4 alkyl group may be substituted by or substituted by a substituent selected from the group consisting of groups of the heterocyclic saturated 5-or 6-can not be a substituted or unsubstituted C _1-8 alkyl group the display or, R ⁴ and R ⁵ together with the adjacent nitrogen atom and, optionally, one or more further nitrogen and / or oxygen and / or sulfur atoms, C _1-4 alkyl group; Or substituted by a C _1-4 alkoxy or substituted by an unsubstituted phenyl group or to form an unsubstituted saturated 5-to 10-membered heterocyclic ring, and R ² and R ³ a group of amino group, and one of the groups group, or one or more nitrogen and / or oxygen and / or containing a sulfur atom and is bonded by a nitrogen atom, C _1-4 alkyl group, a phenyl group or a halo-substituted by a phenyl group or unsubstituted 5-to 10-membered saturated heterocyclic ring represents a group or, R ² and R ³ a group of the formula -SR meaning, R is an alkenyl substituted or unsubstituted C _1-8 alkyl, C _2-6 by a phenyl group or a halophenyl group or groups in the formula -SR C of _2-6 alkynyl group represents the amino group, or both groups is a group consisting of C _1-6 alkyl, C _2-6 alkenyl, phenyl (C _1-4 alkyl) group or a halophenyl (C _1-4 alkyl) one or two selected from the values It is replaced by the body.