Effects of sulfur dioxide and its derivatives on the functions of rat hearts and their mechanisms

机译：二氧化硫及其衍生物对大鼠心脏功能的影响及其机制

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The present study was designed to investigate the mechanisms underlying the effects of SO2 on functions of the isolated perfused hearts in rats.The results suggest that both SO2 and SO2 derivatives (sulfite:bisulfite,3:1,M/M) elicited a negative inotropic effect.At high concentrations,the effects of SO2 or its derivatives on heart functions might be related to the increasing of reactive oxygen species (ROS) contents and decreasing of ATPase activities as well as the potentially damaging effects on the hearts; while at low concentrations,SO2 or its derivatives might modulate heart functions mainly through the NO signal transduction pathway.

机译：本研究旨在探讨SO2对大鼠离体灌注心脏功能的潜在机制，结果表明SO2和SO2衍生物（亚硫酸盐：亚硫酸氢盐，3：1，M / M）均引起负性变力作用在高浓度下，SO2或其衍生物对心脏功能的影响可能与活性氧（ROS）含量的增加和ATPase活性的下降以及对心脏的潜在破坏作用有关。在低浓度时，SO2或其衍生物可能主要通过NO信号转导途径调节心脏功能。

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来源
《Proceedings of 2013 international symposium on environmental science and technology》|2013年|32-37|共6页
会议地点 Dalian(CN)
作者
Quanxi Zhang; Jingjing Tian; Yunlong Bai; Zhenhua Yang; Huifang Zhang; Ziqiang Meng;
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作者单位

Institute of Environmental Medicine and Toxicology, Research Center of Environmental Science and Engineering, Shanxi University, Wucheng Road 92#, Taiyuan 030006, China;

Institute of Environmental Medicine and Toxicology, Research Center of Environmental Science and Engineering, Shanxi University, Wucheng Road 92#, Taiyuan 030006, China;

Institute of Environmental Medicine and Toxicology, Research Center of Environmental Science and Engineering, Shanxi University, Wucheng Road 92#, Taiyuan 030006, China;

Institute of Environmental Medicine and Toxicology, Research Center of Environmental Science and Engineering, Shanxi University, Wucheng Road 92#, Taiyuan 030006, China;

China Institute for Radiation Protection, Xuefu Street 102#, Taiyuan 030006, China;

Institute of Environmental Medicine and Toxicology, Research Center of Environmental Science and Engineering, Shanxi University, Wucheng Road 92#, Taiyuan 030006, China;

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原文格式 PDF
正文语种 eng
中图分类环境科学基础理论;
关键词
sulfur dioxide; SO2 derivatives; heart function; inotropic effect;

机译：二氧化硫; SO2衍生物；心功能变力作用;
入库时间 2022-08-26 14:05:37

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专利

1. The Negative Inotropic Effects of Gaseous Sulfur Dioxide and Its Derivatives in the Isolated Perfused Rat Heart [J] . Quanxi Zhang, Ziqiang Meng Environmental toxicology . 2012,第3a4期

机译：气体二氧化硫及其衍生物对离体大鼠心脏的负性肌力作用
2. The vasodilator effect and its mechanism of sulfur dioxide-derivatives on isolated aortic rings of rats. [J] . Meng Z, Zhang H Inhalation toxicology . 2007,第11期

机译：二氧化硫衍生物对大鼠离体主动脉环的血管舒张作用及其机制。
3. The ERK1/2 Signaling Pathway Is Involved in Sulfur Dioxide Preconditioning-Induced Protection against Cardiac Dysfunction in Isolated Perfused Rat Heart Subjected to Myocardial Ischemia/Reperfusion [J] . Angie Dong Liu, Chaoshu Tang, Hongfang Jin, International Journal of Molecular Sciences . 2013,第11期

机译：ERK1 / 2信号通路涉及二氧化硫预处理诱导的针对心肌缺血/再灌注的离体灌流大鼠心脏的功能障碍。
4. Effects of sulfur dioxide and its derivatives on the functions of rat hearts and their mechanisms [C] . Quanxi Zhang, Jingjing Tian, Yunlong Bai, International symposium on environmental science and technology . 2013

机译：二氧化硫及其衍生物对大鼠心脏功能的影响及其机制
5. Carbon dioxide displacement mechanisms: Phase equilibria effects and carbon dioxide sequestration studies. [D] . Pasala, Sangeetha M. 2010

机译：二氧化碳置换机制：相平衡效应和二氧化碳螯合研究。
6. The ERK1/2 Signaling Pathway Is Involved in Sulfur Dioxide Preconditioning-Induced Protection against Cardiac Dysfunction in Isolated Perfused Rat Heart Subjected to Myocardial Ischemia/Reperfusion [O] . Pan Huang, Yan Sun, Jinyan Yang, 2013

机译：ERK1 / 2信号通路涉及二氧化硫预处理诱导的针对心肌缺血/再灌注的离体灌流大鼠心脏的功能障碍。
7. Effects of Sulfur Dioxide and Its Derivatives on the Functions of Rat Hearts and their Mechanisms [O] . Zhang Quanxi, Tian Jingjing, Bai Yunlong, 2013

机译：二氧化硫及其衍生物对大鼠心脏功能的影响及其机制

Effects of sulfur dioxide and its derivatives on the functions of rat hearts and their mechanisms

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