FIELD: organic chemistry. SUBSTANCE: described is method of preparing 3-ethyl-5-methyl ester of 2-[2-(N-phthalimido)ethoxymethyl-4-(2-chlorphenyl)-1,4-dihydro-6- methyl-3,5-pyridinedicaroxylic acid of formula I: by reacting 2- chlorobenzaldehyde with 4-[2-(N-phthalimido)ethoxyacetoacetic acid ethyl ester in isopropyl alcohol solvent using pyridine, piperidine or salt s thereof as catalyst at temperatures from 25 C 35 C to gibe benzylidine derivative of 4-[2- (N-phthalimido)aceto acetic acid ethyl ester which is reacted with methylaminoprotonate added in portions to acetic acid at temperatures from 35 to 55 C to give product. EFFECT: more efficient preparation method. 3 cl, 1 dwg, 1 ex
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机译:领域:有机化学。物质:描述了2- [2-(N-邻苯二甲酰亚胺基)乙氧基甲基-4-(2-氯苯基)-1,4-二氢-6-甲基-3,5-的3-乙基-5-甲酯的制备方法式I的吡啶二烷氧基酸:通过使2-氯代苯甲醛与二氯苯甲醛反应,在吡啶醇,哌啶或其盐作为催化剂的异丙醇溶剂中,在25°C至35°C的温度下,由4- [2-(N-邻苯二甲酰亚胺基)乙氧基乙酰乙酸乙酯制成4- [2-(N-邻苯二甲酰亚胺基)的苄基衍生物在35至55℃的温度下,将乙酰乙酸乙酯与乙酰氨基甲酸酯反应,将其分批加入到乙酸中,得到产物。效果:更有效的制备方法。 3 cl,1 dwg,1 ex
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