FIELD: chemical industry. SUBSTANCE: method comprises reacting 3-ethyl-5-methyl ester of 2-[2-(N- phthalimido)ehtoxymethyl)-4-(2-chlorophenyl) 1,4-dihydro- 6-methyl-3,5-pyridine dicarboxylic acid with N-methyl ammonium salt of benzenesulfonic acid in secondary alcohol solvent at temperature of 75-80 C and isolating desired compound by well known procedure. It is desirable to use isopropyl alcohol solvent and to purify final compound by crystallization from water. Method makes it possible to prepare desired product in one stage without isolation of amplodipin base, to use commercially available substances and to use water for crystallization. EFFECT: more efficient preparation method. 3 cl, 2 ex
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机译：领域：化学工业。物质：该方法包括使2- [2-（N-邻苯二甲酰亚胺基）乙氧基甲基）-4-（2-氯苯基）1,4-二氢-6-甲基-3,5-吡啶二羧酸的3-乙基-5-甲酯反应在仲醇溶剂中，在75-80℃的温度下，用苯磺酸的N-甲基铵盐与丙烯酸反应，并通过众所周知的方法分离出所需化合物。希望使用异丙醇溶剂并通过从水中结晶来纯化最终化合物。该方法使得可以在不分离扩增二苯并啶碱的情况下一步制备所需产物，使用市售物质并使用水进行结晶。效果：更有效的制备方法。 3 cl，2 ex
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