MUTATIONS OF MTS GENE IN EMBRYONIC LINE AND METHOD OF DETECTION OF PREDISPOSITION TO MALIGNANT TUMORS

摘要

FIELD: medicine, medicinal genetics. SUBSTANCE: invention relates to somatic mutations in gene multifunctional tumor suppressor (MTS) in the case of human neoplasia and use of these mutations for diagnosis and prognosis of indicated diseases. Invention relates also to mutations of MTS gene in embryonic line and use of these mutations for diagnosis of predisposition to different forms of cancer, for example, melanoma, ocular melanoma, leukosis, astrocytoma, glyoblastoma, lymphoma, glyoma, Hodgkin's disease, multiple myeloma, sarcoma, myosarcoma, cholangiosarcoma, squamous carcinoma, chronic lymphoid lympholeukosis and also tumors of pancreas, breast, brain, prostate, bladder, thyroid, ovary, uterus, testicle, kidney, stomach, colon and straight intestine. Invention relates also to therapy of human neoplasia where mutation occurred in MTS gene involving genetic therapy substituting protein therapy and use of protein mimetics. EFFECT: broadened arsenal of methods for preparations screening in aims of tumors therapy. 33 cl, 25 dwg, 18 ex