MTS GENE, MUTATIONS OF THIS GENE AND METHODS OF DIAGNOSIS OF MALIGNANT TUMORS USING MTS GENE SEQUENCE

摘要

FIELD: medicine, oncology, medicinal genetics. SUBSTANCE: invention relates to somatic mutations in gene of multifunctional tumor suppressor (MTS) in the case human neoplasia and using these mutations for diagnosis and prognosis of oncological diseases. Invention relates to mutations of MTS gene in embryonic line and using these mutations for diagnosis of diathesis to the following cancer forms: melanoma, ocular melanoma, leukosis, astrocytoma, glyoblastoma, lymphoma, glyoma, Hodgkin's lymphoma, multiple myeloma, sarcoma, myosarcoma, cholangiosarcoma, squamous cell carcinoma, chronic lymphoid lympholeukosis and pancreas, ovary, uterine, testis, kidney, stomach, colon and straight intestine tumors also. Invention relates to also therapy of human neoplasia where mutation in MTS gene occurred including genetic therapy, substitution protein therapy and mimetics using. EFFECT: broadened arsenal of agents used for diagnosis and therapy of tumors. 53 cl, 9 tbl, 25 dwg