PACLITAXEL DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHOD OF TUMOR GROWTH INHIBITION

摘要

FIELD: organic chemistry, medicine, oncology, pharmacy. SUBSTANCE: invention describes novel compounds of the formula (I) where R¹ is OC(O)R^x; R² is hydroxy-group; R² is hydrogen atom; R⁶ or hydrogen atom; R⁶ is hydrogen atom; R⁸ is methyl-group; R⁹ is OC(O)R^x; R⁷ and R⁷ in common form oxo-group; R⁴ and R⁵ mean phenyl-group; p = 0; R^d and R^e mean hydrogen atom; R^f means hydrogen atom; R^x means C_1-6-alkyl or R^x means radical of the formula where D means a bond or C_1-6-alkyl and R^a, R^b, R^c means hydrogen atom independently, or their pharmaceutically acceptable salts. These compounds show antitumor activity and are used for preparing pharmaceutical composition for inhibition of tumor growth in bearing mammal. EFFECT: new compounds indicated above, improved method of tumor growth inhibition, valuable antitumor activity. 7 cl, 7 ex