ANTIBODY SPECIFIC FOR A HAEMOSTATIC PROTEIN; ITS USE FOR INSULATION OF INTACT PROTEIN; HAEMOSTATIC COMPOSITIONS WITHOUT PROTEOLYTIC SPLIT PRODUCTS OF THE PROTEIN

摘要

A method for the generation of Ca++ independent antibodies against blood coagulation factors is described wherein an antibody selection strategy based upon small peptides comprising target sequences for limited proteolysis is employed. These antibodies which distinguish between intact and cleaved species of haemostatic protein provide novel tools for the isolation of intact haemostatic proteins.